THERAPEUTIC POTENTIAL OF GINSENOSIDES IN DIABETES - A BRIEF REVIEW

Abstract

Ginsenoside is a triterpenoid saponin extracted from Panax ginseng forms the active ingredient in ginseng, widely used in clinical practice as the main component of injections, granules, common tablets, dispersible tablets, capsules, and mixtures; thus, it has become a target of extensive research. They have been emerged to support antidiabetic efficacy for ginsenosides ascribe to their antioxidant, anti-inflammatory, and anti-hyperglycemic activities. A meta-analysis showed that ginseng reduced fasting blood glucose in patients. Ginseng also exerted antidiabetic effects as a supplemental treatment. Ginseng extracts significantly improved glucose tolerance, improved in plasma glucose and insulin levels.. Besides, studies on ginsenosides in pharmaceutical preparations have also been limited. Therefore, this review dominantly discusses the roles and mechanisms of ginsenosides in the intervention of blood glucose elevation, as well as the current clinical trials on ginsenosides pharmacology. The elucidation of molecular mechanisms and clinical trials at diabetic status could facilitate ginsenosides application in herbal medicines