POTENTIAL TEST OF TURMERIC ETHANOL EXTRACT CREAM FOR WOUND HEALING IN WISTAR RATS

Abstract

The shape of the wound is different depending on the cause; some are open and closed, and the healing consists of several phases, namely the inflammatory phase, proliferative phase, and maturation phase. Several sources state that turmeric rhizome extract is effective in wound healing. This study aimed to test the potential of turmeric rhizome extract to be effective in wound healing. This type of research is experimental with a Pre-test and Post-test group-control design approach, conducted from November to December 2020. The samples used were turmeric rhizomes (Curcuma Longa) and male white rats. Determination of sample size according to Frederer's formula, so the number of pieces was 25 rats, the division of 4 treatment groups and one control group. The data will be analyzed for normality and continued with the ANOVA test. The results of turmeric extract contain chemical compounds of alkaloids, flavonoids, saponins, and tannins. The results of the Fcount value of 8.442 ≥ Ftable of 2.67, with a p-value of 0.004 ≤ 0.05, state that turmeric extract administration significantly affects wound healing in rats. The optimum concentration of turmeric ethanol extract (Curcuma Longa) that can heal cut wounds in white rats is 6%. The highest percentage of healing on day k-14 was in positive control (Bioplacenton®), which was 95%, followed by 6% v/v extract. The cream preparation of turmeric ethanol extract (Curcuma Longa) has an ability that is close to Bioplacenton® in healing cut wounds in rats.