ANALYSIS OF THE EFFECTIVENESS OF ARECA NUT EXTRACT IN WOUND HEALING AFTER TOOTH EXTRACTION IN WISTAR RATS

Abstract

One of the plants that is often used by the community for wound healing is areca nut (Areca catechu L) which is spread throughout Indonesia. Areca nut (Areca catechu L) seeds contain phytochemical compounds that are beneficial for wound healing such as antioxidants, anti-inflammatory, and antibacterial compound. The purpose of this study was to analyse the effectiveness of Areca nut (Areca catechu L.) seed extract in accelerating wound healing time after tooth extraction. This experimental laboratory study uses a randomized controlled design with a post-test only control group design pattern. The experimental animals used in this study are Wistar rats, 32 males, physically healthy, 2-3 months old, with a body weight between 200-250 grams. The rats will be divided into two groups, namely, 16 treated with 60% Areca nut (Areca catechu L) and 16 treated with 120% Areca nut (Areca catechu L) to see the comparison of accelerated wound healing after tooth extraction. Data analysis using the SPSS 16 program, research using a pure experiment with a non-parametric Chi-Square Test, after testing, showed that (p <0.05) means there is a significant difference between groups. Results there is a significant relationship between the number of fibroblast tissue per field of view in Wistar rats after tooth extraction by giving Areca nut extract (Areca catechu L.) with a concentration of 60% and Areca nut extract (Areca catechu L.) concentration of 120%%, p = 0.001 (p <0.05). concluded that areca nut extract (Areca catechu L.) 60% and 120% are effective in accelerating wound healing time after tooth extraction of Wistar rats.