PATHOGENETIC MECHANISM OF DEVELOPMENT OF INSULIN RESISTANCE IN CHRONIC VIRAL HEPATITIS C

Abstract

The purpose of the study; to determine the pathogenic mechanism of the development of insulin resistance in CVHC (chronic viral hepatitis C).  Research methods: during the examination at the Virology Scientific Research Institute, 90 patients were examined and genotype and viral load of VHC (viral hepatitis C) in these patients was determined using PCR (polymerase chain reaction) and divided into small groups.In these small groups, glycaemic index indices were determined and evaluated in patients.

Results: among the carbohydrate indicators according to the genotype in the patients we examined, the results of the study showed that HOMA index was 3,7±0,43 in patients typical to type 1 genotypeand significantly increased compared to other examined 2 and 3 genotypes(r<0,05). Thus, patients with type 1 genotype HCV have a higher risk of developing DM type 2 than those with type 2 and 3 genotypes. In patients with high viremia, the content of morning blood sugar was 5.9±0.16 (P<0.001) and HOMA index was 4.6±0.87(P<0.05)

Conclusion: in patients with 1b genotype of CVGC, a reliable increase in insulin resistance indicators was identified in relation to genotype 3 a (r<0,001). Increased viremia caused a dramatic increase in glycemia and HOMA index (r<0,001). In the correlation analysis, a strong bond was formed between the increase in viral load and the NOMA index(r=0,71).