FORMULATION AND EVALUATION OF GLYCEROGELATIN BASED MELOXICAM TRANSDERMAL PATCH

Abstract

The objective of the study was to develop and evaluate Glycerogelatin based Meloxicam (NSAIDS) Trandermal patch. The study aimed to create a monolithic transdermal therapeutic system for meloxicam using hydroxyl propyl methyl cellulose (HPMC) as a polymer rand gelatin, glycerin, and ethanol as plasticizer, penetration enhancer, and permeation enhancer, respectively, through solvent casting evaporation method. The transdermal patch was evaluated for various parameters, including physical appearance, folding endurance, moisture content, weight variation, drug content uniformity, and in-vitro drug release studies. The article also provides the methodology and experimental work that was done to prepare the transdermal patch, which involved heating gelatin with water, adding HPMC and glycerin, dissolving meloxicam in ethanol, and mixing and sonication of the solutions. The formulation chart of the glycerogelatin based meloxicam transdermal patch is also provided. The article discusses the advantages of transdermal patches over other routes of administration and highlights the potential of meloxicam transdermal patches to provide improved convenience, reduced side effects, consistent drug delivery.