DESIGN AND EVALUATION OF HYDRALAZINE MOUTH DISSOLVING TABLET
Keywords:
Hydralazine, Hypertension, Mouth Dissolving Tablet,orally disintegrating tablet, Precompressional studies, disintegration time.Abstract
Hydralazine is the first-line therapy for hypertension in pregnancy. Hydralazine is used to treat severe hypertension, but it is not a first-line therapy for essential hypertension. Tablet dosage form is the most popular among all existing conventional dosage forms because of its convenience of self administration, compactness and easy manufacturing. Many patients find it difficult to swallow tablets and capsules.Mouth Dissolving Tablets is a solid dosage form that dissolves or disintegrates within a minute in the oral cavity without the need of water and has a pleasant taste. MDT is also known as orally disintegrating tablet, fast-dissolving tablet, fast-melting tablet, mouth melting tablet or fast-disintegrating tablet.The formulas were evaluated for compatibility and Precompressional studies. The formulations were evaluated for weight variation, thickness, hardness, friability, content uniformity, disintegration time, wetting time, water absorption ratio and release profile.
